Dev128215 4119..4128
نویسندگان
چکیده
Precise control of oligodendrocyte migration and development is crucial for myelination of axons in the central nervous system (CNS), but important questions remain unanswered about the mechanisms controlling these processes. In a zebrafish screen for myelination mutants, we identified amutation in zinc finger protein 16-like (znf16l). znf16l mutant larvae have reduced myelin basic protein (mbp) expression and reduced CNS myelin. Marker, time-lapse and ultrastructural studies indicated that oligodendrocyte specification, migration andmyelination are disrupted in znf16lmutants. Transgenic studies indicated that znf16l acts autonomously in oligodendrocytes. Expression of Zfp488 from mouse rescued mbp expression in znf16l mutants, indicating that these homologs have overlapping functions. Our results defined the function of a new zinc finger protein with specific function in oligodendrocyte specification, migration and myelination in the developing CNS.
منابع مشابه
Detailed correction to: Computational identification of noncoding RNAs in Saccharomyces cerevisiae by comparative genomics
In Nucleic Acids Res. [REF], we issued a correction for our article, Computational identification of non-coding RNAs in Saccharomyces cerevisiae by comparative genomics (Nucleic Acids Res. 31: 4119-4128, 2003). This paper reported eight new noncoding RNA genes in yeast, named RUF1 through RUF8, for “RNA of Unknown Function.” We subsequently found that we cannot verify the transcription of three...
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